This paper discusses two major issues associated with channel crosstalk that have not been fully addressed previously: models from measurements and algorithms for BER prediction. It presents a practical solution that allows designers to add in “near-end” or “far-end” crosstalk characterized by a group of 4-port S-parameters, rather than to perform multiport parameter characterization. The paper then presents in details two simulation approaches for channel crosstalk: synchronous and asynchronous algorithms, and considers their implementations in time and statistical domains. Finally, it gives examples of the proposed procedures implemented together with IBIS-AMI buffer models and discusses their comparative advantages and limitations.